The Centro Cultural Santo Domingo is located in the Ex-Convento de Santo Domingo, 5 blks N and 2 blocks east of the NE corner of the zócalo. (951) 516-2991, 516-3721. The 16th century ex-convent houses an enormous collection of pre-Columbian and colonial artifacts, including items retrieved from Monte Albán. Adjacent botanical garden. Open 10:00 - 7:30 pm daily except closed Mondays. See an essay by Stan Gotlieb, A World Class Museum Opens in Oaxaca.
Also located in the 4-block complex is the Church of Santo Domingo.